Illuminating the impact of CD38-induced adenosine formation in B-cell lymphoma

Illuminating the impact of CD38-induced adenosine formation in B-cell lymphoma

Abstract The expression of CD38 by cancer cells may mediate an immune-suppressive effect by producing Extracellular Adenosine (ADO) acting through G-protein-coupled cell surface receptors on cellular components and tumor cells. This can increase PD-1 expression and interaction with PD-L1, suppressin...

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Bibliographic Details
Main Authors: Shams ElDoha Galal ElDin Zaiema, Heba Mohamed Saber Hafez, Diaa El-Din Moussa Sherif Abou El-Ela, Rawda Ahmed Alaaeldin Ahmed Mohamed Saad
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Scientific Reports
Subjects:
CD38 expression
Extracellular ADO
Mature B-cell lymphoma
Chronic lymphocytic leukemia
B-Non-Hodgkin lymphoma
PD-1/PD-L1 axis
Online Access:https://doi.org/10.1038/s41598-024-82800-1
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