5-methoxytryptophan ameliorates renal ischemia/reperfusion injury by alleviating endoplasmic reticulum stress-mediated apoptosis through the Nrf2/HO-1 pathway

5-methoxytryptophan ameliorates renal ischemia/reperfusion injury by alleviating endoplasmic reticulum stress-mediated apoptosis through the Nrf2/HO-1 pathway

BackgroundRenal ischemia/reperfusion (I/R) injury is a prevalent clinical complication characterized by high incidence and mortality rates. The endogenous metabolite, 5-Methoxytryptophan (5-MTP), derived from tryptophan, possesses anti-inflammatory and antioxidant properties. However, its role in re...

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Bibliographic Details
Main Authors: Shaona Li, Hongjuan Yang, Bing Zhang, Lingyu Li, Xiangkun Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Pharmacology
Subjects:
5-methoxytryptophan
ischemia-reperfusion injury
endoplasmic reticulum stress
apoptosis
nuclear factor erythroid-2 related factor 2
heme oxygenase-1
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1506482/full
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https://www.frontiersin.org/articles/10.3389/fphar.2025.1506482/full

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