Maternal high-fat diet orchestrates offspring hepatic cholesterol metabolism via MEF2A hypermethylation-mediated CYP7A1 suppression

Maternal high-fat diet orchestrates offspring hepatic cholesterol metabolism via MEF2A hypermethylation-mediated CYP7A1 suppression

Abstract Background Maternal overnutrition, prevalent among women of childbearing age, significantly impacts offspring health throughout their lifetime. While DNA methylation of metabolic-related genes mediates the transmission of detrimental effects from maternal high-fat diet (HFD), its role in pr...

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Bibliographic Details
Main Authors: Ling Zhang, Wenyu Zou, Shixuan Zhang, Honghua Wu, Ying Gao, Junqing Zhang, Jia Zheng
Format: Article
Language:English
Published: BMC 2024-12-01
Series:Cellular & Molecular Biology Letters
Subjects:
maternal HFD
hepatic cholesterol metabolism
MEF2A
CYP7A1
DNA methylation
offspring
Online Access:https://doi.org/10.1186/s11658-024-00673-8
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https://doi.org/10.1186/s11658-024-00673-8

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