A redundant isoprenoid biosynthetic pathway supports Staphylococcus aureus metabolic versatility

A redundant isoprenoid biosynthetic pathway supports Staphylococcus aureus metabolic versatility

ABSTRACT Isoprenoids are ubiquitous molecules that serve as fundamental building blocks for life. In bacteria, isoprenoids are precursors for carotenoid pigments, respiratory cofactors, and essential sugar carrier lipids, such as lipid II. Isoprenoid synthesis initiates via condensation of the five-...

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Main Authors: Troy A. Burtchett, Elizabeth N. Ottosen, Tomotaka Jitsukawa, Momoko Kaneko, Miu Yasui, Jessica A. Lysne, Paige J. Kies, Jessica A. Bailey, Sean M. Thomas, Shingo Fujisaki, Neal D. Hammer
Format: Article
Language:English
Published: American Society for Microbiology 2025-08-01
Series:mBio
Subjects:
isoprenoid
bacterial respiration
terminal oxidase
menaquinone
Staphylococcus aureus
farnesyl diphosphate
Online Access:https://journals.asm.org/doi/10.1128/mbio.00353-25
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https://journals.asm.org/doi/10.1128/mbio.00353-25

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