Revisiting synthetic lethality of Gcn5-related N-acetyltransferase (GNAT) family mutations in Haloferax volcanii

Revisiting synthetic lethality of Gcn5-related N-acetyltransferase (GNAT) family mutations in Haloferax volcanii

ABSTRACT Lysine acetylation is a post-translational modification that occurs in all domains of life, highlighting its evolutionary significance. Previous genome comparison identified three Gcn5-related N-acetyltransferase (GNAT) family members as lysine acetyltransferase homologs (Pat1, Pat2, and El...

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Main Authors: Katherine R. Weber, Brianna Novillo, Julie A. Maupin-Furlow
Format: Article
Language:English
Published: American Society for Microbiology 2025-08-01
Series:Microbiology Spectrum
Subjects:
archaea
post-translational modification
lysine acetyltransferase
mutant generation
Haloferax volcanii
Online Access:https://journals.asm.org/doi/10.1128/spectrum.01229-25
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https://journals.asm.org/doi/10.1128/spectrum.01229-25

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