Innate immune response to Streptococcus pyogenes depends on the combined activation of TLR13 and TLR2.

Innate immune response to Streptococcus pyogenes depends on the combined activation of TLR13 and TLR2.

Innate immune recognition of the major human-specific Gram-positive pathogen Streptococcus pyogenes is not understood. Here we show that mice employ Toll-like receptor (TLR) 2- and TLR13-mediated recognition of S. pyogenes. These TLR pathways are non-redundant in the in vivo context of animal infect...

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Main Authors: Christina Fieber, Marton Janos, Tina Koestler, Nina Gratz, Xiao-Dong Li, Virginia Castiglia, Marion Aberle, Martina Sauert, Mareike Wegner, Lena Alexopoulou, Carsten J Kirschning, Zhijian J Chen, Arndt von Haeseler, Pavel Kovarik
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0119727
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https://doi.org/10.1371/journal.pone.0119727

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