Spatiotemporal Characterization of Human Early Intervertebral Disc Formation at Single‐Cell Resolution

Spatiotemporal Characterization of Human Early Intervertebral Disc Formation at Single‐Cell Resolution

Abstract The intervertebral disc (IVD) acts as a fibrocartilaginous joint to anchor adjacent vertebrae. Although several studies have demonstrated the cellular heterogeneity of adult mature IVDs, a single‐cell transcriptomic atlas mapping early IVD formation is still lacking. Here, the authors gener...

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Main Authors: Taifeng Zhou, Yu Chen, Zhiheng Liao, Long Zhang, Deying Su, Zhuling Li, Xiaoming Yang, Xiaona Ke, Hengyu Liu, Yuyu Chen, Ricong Weng, Huimin Shen, Caixia Xu, Yong Wan, Ren Xu, Peiqiang Su
Format: Article
Language:English
Published: Wiley 2023-05-01
Series:Advanced Science
Subjects:
annulus fibrosus
intervertebral disc formation
notochord
nucleus pulposus
single‐cell RNA sequencing
Online Access:https://doi.org/10.1002/advs.202206296
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