Protein disulfide isomerase integrates toll-like receptor 4 and P2X7 receptor signaling pathways during lipopolysaccharide-induced neuroinflammation

Protein disulfide isomerase integrates toll-like receptor 4 and P2X7 receptor signaling pathways during lipopolysaccharide-induced neuroinflammation

Abstract P2X7 receptor (P2X7R) augments lipopolysaccharide (LPS)-toll-like receptor 4 (TLR4)-mediated neuroinflammation. These roles of P2X7R in neuroinflammation are relevant to nitrosative stress through nuclear factor-κB (NF-κB)-inducible nitric oxide synthase (iNOS) pathway, while the underlying...

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Bibliographic Details
Main Authors: Ji-Eun Kim, Su Hyeon Wang, Duk-Shin Lee, Tae-Hyun Kim
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:Scientific Reports
Subjects:
Astrocyte
LPS
Microglia
Nitrosative stress
S-nitrosylation
SN50
Online Access:https://doi.org/10.1038/s41598-025-92780-5
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https://doi.org/10.1038/s41598-025-92780-5

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