Discovering the inhibition of YAP/TEAD Hippo signaling pathway via new pyrazolone derivatives: synthesis, molecular docking and biological investigations

Discovering the inhibition of YAP/TEAD Hippo signaling pathway via new pyrazolone derivatives: synthesis, molecular docking and biological investigations

Abstract Heterocyclic compounds play a crucial role in the drug discovery process and development due to their significant presence and importance. Here, we report a comprehensive analysis of new pyrazolone derivatives, prepared according to a clear-cut, uncomplicated procedure. The pyrazolone deriv...

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Bibliographic Details
Main Authors: Ahmed A. Noser, Maha M. Salem, Mohamed H. Baren, Adel I. Selim, Esraa M. ElSafty
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:Scientific Reports
Subjects:
Pyrazolone
Molecular docking
Antioxidant
Hippo signaling pathway
ADMET
Online Access:https://doi.org/10.1038/s41598-024-79992-x
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https://doi.org/10.1038/s41598-024-79992-x

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