Disease-Associated Dopamine Receptor D2 Variants Exhibit Functional Consequences Depending on Different Heterotrimeric G-Protein Subunit Combinations

Disease-Associated Dopamine Receptor D2 Variants Exhibit Functional Consequences Depending on Different Heterotrimeric G-Protein Subunit Combinations

<b>Background:</b> Dopamine receptors (DRs) are G-protein-coupled receptors (GPCRs) found in the central nervous system (CNS). DRs are essential for mediating various downstream signaling cascades and play a critical role in regulating the dopaminergic nigrostriatal pathway, which is inv...

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Bibliographic Details
Main Authors: Nele Niebrügge, Olga Trovato, Roman Praschberger, Andreas Lieb
Format: Article
Language:English
Published: MDPI AG 2024-12-01
Series:Biomedicines
Subjects:
GPCRs
dopamine receptors
movement disorders
Online Access:https://www.mdpi.com/2227-9059/13/1/46
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