Evaluation of the Anti-Mycobacterial and Anti-Inflammatory Activities of the New Cardiotonic Steroid γ-Benzylidene Digoxin-15 in Macrophage Models of Infection

Evaluation of the Anti-Mycobacterial and Anti-Inflammatory Activities of the New Cardiotonic Steroid γ-Benzylidene Digoxin-15 in Macrophage Models of Infection

Cardiotonic steroids modulate various aspects of the inflammatory response. The synthetic cardiotonic steroid γ-benzylidene digoxin 15 (BD-15), a digoxin derivative, has emerged as a promising candidate with potential immunomodulatory effects. However, its biological activity remains largely unexplo...

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Main Authors: Daniel Wilson A. Magalhães, Maria Gabriella S. Sidrônio, Noêmia N. A. Nogueira, Deyse Cristina Madruga Carvalho, Maria Eugênia G. de Freitas, Ericke Cardoso Oliveira, Gustavo F. de Frazao Lima, Demétrius A. M. de Araújo, Cristoforo Scavone, Thalisson Amorim de Souza, José Augusto F. P. Villar, Leandro A. Barbosa, Francisco Jaime Bezerra Mendonça-Junior, Valnês S. Rodrigues-Junior, Sandra Rodrigues-Mascarenhas
Format: Article
Language:English
Published: MDPI AG 2025-01-01
Series:Microorganisms
Subjects:
tberculosis
drug development
host-directed therapy
anti-inflammatory
benzylidene digoxin
Online Access:https://www.mdpi.com/2076-2607/13/2/269
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