Protective role of coenzyme Q10 against trihexyphenidyl-induced pulmonary toxicity in Wistar rats

Protective role of coenzyme Q10 against trihexyphenidyl-induced pulmonary toxicity in Wistar rats

Abstract Background Trihexyphenidyl (THP), an anticholinergic drug used to manage Parkinson’s disease and dystonia, has been associated with oxidative stress and metabolic disturbances, particularly affecting pulmonary function. Long-term exposure to THP may induce lung toxicity through increased ox...

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Main Authors: Joseph Gbenga Omole, Lydia Oluwatoyin Ajayi, Itunuoluwa Rachael Ajewole, Teniola Osholonge, Oyedayo Phillips Akano, Ayodeji Folorunsho Ajayi
Format: Article
Language:English
Published: BMC 2025-05-01
Series:BMC Pharmacology and Toxicology
Subjects:
Coenzyme Q10
Trihexyphenidyl
Oxidative stress
Lung toxicity
Antioxidant enzymes
Lactate dehydrogenase
Online Access:https://doi.org/10.1186/s40360-025-00955-7
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https://doi.org/10.1186/s40360-025-00955-7

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