Endothelial MT1‐MMP targeting limits intussusceptive angiogenesis and colitis via TSP1/nitric oxide axis

Endothelial MT1‐MMP targeting limits intussusceptive angiogenesis and colitis via TSP1/nitric oxide axis

Abstract Pathological angiogenesis contributes to cancer progression and chronic inflammatory diseases. In inflammatory bowel disease, the microvasculature expands by intussusceptive angiogenesis (IA), a poorly characterized mechanism involving increased blood flow and splitting of pre‐existing capi...

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Main Authors: Sergio Esteban, Cristina Clemente, Agnieszka Koziol, Pilar Gonzalo, Cristina Rius, Fernando Martínez, Pablo M Linares, María Chaparro, Ana Urzainqui, Vicente Andrés, Motoharu Seiki, Javier P Gisbert, Alicia G Arroyo
Format: Article
Language:English
Published: Springer Nature 2019-12-01
Series:EMBO Molecular Medicine
Subjects:
inflammatory bowel disease
intussusceptive angiogenesis
MT1‐MMP
nitric oxide
TSP1
Online Access:https://doi.org/10.15252/emmm.201910862
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https://doi.org/10.15252/emmm.201910862

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