L-carnitine ameliorates myocardial injury by alleviating endoplasmic reticulum stress via inhibition of PERK pathway in exertional heatstroke rats

L-carnitine ameliorates myocardial injury by alleviating endoplasmic reticulum stress via inhibition of PERK pathway in exertional heatstroke rats

Exertional heatstroke (EHS) is a life-threatening condition with potential for tissues and organs injury, including heart. Effective drug strategies to treat patients with EHS are warranted to unlock the therapeutic potential. Considering the cardioprotective effects of L-carnitine (LC), this study...

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Main Authors: Bo-Yi Zhang, Gen-Lin He, Ze-Ze Wang, Huan Zhou, Xue-Yan Huang, Ting-Ting Shen, Xiao-Qian Liu, Yi-Shan Liu, Zhen Luo, Ping Li, Yu-Long Tan, Xue Luo, Xue-Sen Yang
Format: Article
Language:English
Published: Elsevier 2024-11-01
Series:Heliyon
Subjects:
L-carnitine
Exertional heatstroke
Myocardial apoptosis
Endoplasmic reticulum stress
Mitochondrial damage
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844024165334
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