Reduced Schiff-base derivatives to stop reactive oxygen species production by the Cu(A$\beta $) species: a structure–activity relationship
A${\beta }$ is the peptide involved in Alzheimer’s disease. Its binding to the redox copper ions and the subsequent production of reactive oxygen species (ROS) contributing to the overall oxidative stress observed in the disease is among the deleterious effects A${\beta }$ may have. Here seven reduc...
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| Format: | Article |
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Académie des sciences
2023-10-01
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| Series: | Comptes Rendus. Chimie |
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| Online Access: | https://comptes-rendus.academie-sciences.fr/chimie/articles/10.5802/crchim.255/ |
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| author | Lefèvre, Margot Lantigner, Lielou Andolfo, Laura Vanucci-Bacqué, Corinne Benoist, Eric Esmieu, Charlène Bedos-Belval, Florence Hureau, Christelle |
| author_facet | Lefèvre, Margot Lantigner, Lielou Andolfo, Laura Vanucci-Bacqué, Corinne Benoist, Eric Esmieu, Charlène Bedos-Belval, Florence Hureau, Christelle |
| author_sort | Lefèvre, Margot |
| collection | DOAJ |
| description | A${\beta }$ is the peptide involved in Alzheimer’s disease. Its binding to the redox copper ions and the subsequent production of reactive oxygen species (ROS) contributing to the overall oxidative stress observed in the disease is among the deleterious effects A${\beta }$ may have. Here seven reduced Schiff-base ligands were studied for their ability to stop Cu(A${\beta }$)-induced ROS production. The spectroscopic UV–vis and EPR characterizations of the Cu(II) complexes are reported as well. While all the ligands except one are able to stop Cu(A${\beta }$)-induced ROS, only two maintain this ability in the presence of the endogenous Zn ions, due to kinetic competitiveness. |
| format | Article |
| id | doaj-art-9ae39709ef214a5d8e032feabd7d14ae |
| institution | Kabale University |
| issn | 1878-1543 |
| language | English |
| publishDate | 2023-10-01 |
| publisher | Académie des sciences |
| record_format | Article |
| series | Comptes Rendus. Chimie |
| spelling | doaj-art-9ae39709ef214a5d8e032feabd7d14ae2025-02-07T13:38:54ZengAcadémie des sciencesComptes Rendus. Chimie1878-15432023-10-0126S3677710.5802/crchim.25510.5802/crchim.255Reduced Schiff-base derivatives to stop reactive oxygen species production by the Cu(A$\beta $) species: a structure–activity relationshipLefèvre, Margot0https://orcid.org/0009-0006-1924-7937Lantigner, Lielou1Andolfo, Laura2Vanucci-Bacqué, Corinne3https://orcid.org/0000-0002-7232-6267Benoist, Eric4https://orcid.org/0000-0003-0764-9024Esmieu, Charlène5https://orcid.org/0000-0003-1412-033XBedos-Belval, Florence6https://orcid.org/0000-0002-6792-6815Hureau, Christelle7https://orcid.org/0000-0003-3339-0239LCC-CNRS, Université de Toulouse, CNRS, Toulouse, FranceLCC-CNRS, Université de Toulouse, CNRS, Toulouse, FranceLCC-CNRS, Université de Toulouse, CNRS, Toulouse, France; LSPCMIB, CNRS UMR 5068, Université Toulouse III-Paul Sabatier, 118 route de Narbonne, 31062 Toulouse cedex 9, FranceLSPCMIB, CNRS UMR 5068, Université Toulouse III-Paul Sabatier, 118 route de Narbonne, 31062 Toulouse cedex 9, FranceLSPCMIB, CNRS UMR 5068, Université Toulouse III-Paul Sabatier, 118 route de Narbonne, 31062 Toulouse cedex 9, FranceLCC-CNRS, Université de Toulouse, CNRS, Toulouse, FranceLSPCMIB, CNRS UMR 5068, Université Toulouse III-Paul Sabatier, 118 route de Narbonne, 31062 Toulouse cedex 9, FranceLCC-CNRS, Université de Toulouse, CNRS, Toulouse, FranceA${\beta }$ is the peptide involved in Alzheimer’s disease. Its binding to the redox copper ions and the subsequent production of reactive oxygen species (ROS) contributing to the overall oxidative stress observed in the disease is among the deleterious effects A${\beta }$ may have. Here seven reduced Schiff-base ligands were studied for their ability to stop Cu(A${\beta }$)-induced ROS production. The spectroscopic UV–vis and EPR characterizations of the Cu(II) complexes are reported as well. While all the ligands except one are able to stop Cu(A${\beta }$)-induced ROS, only two maintain this ability in the presence of the endogenous Zn ions, due to kinetic competitiveness.https://comptes-rendus.academie-sciences.fr/chimie/articles/10.5802/crchim.255/CopperAlzheimerPeptide2N2O ligandOxidative stress |
| spellingShingle | Lefèvre, Margot Lantigner, Lielou Andolfo, Laura Vanucci-Bacqué, Corinne Benoist, Eric Esmieu, Charlène Bedos-Belval, Florence Hureau, Christelle Reduced Schiff-base derivatives to stop reactive oxygen species production by the Cu(A$\beta $) species: a structure–activity relationship Comptes Rendus. Chimie Copper Alzheimer Peptide 2N2O ligand Oxidative stress |
| title | Reduced Schiff-base derivatives to stop reactive oxygen species production by the Cu(A$\beta $) species: a structure–activity relationship |
| title_full | Reduced Schiff-base derivatives to stop reactive oxygen species production by the Cu(A$\beta $) species: a structure–activity relationship |
| title_fullStr | Reduced Schiff-base derivatives to stop reactive oxygen species production by the Cu(A$\beta $) species: a structure–activity relationship |
| title_full_unstemmed | Reduced Schiff-base derivatives to stop reactive oxygen species production by the Cu(A$\beta $) species: a structure–activity relationship |
| title_short | Reduced Schiff-base derivatives to stop reactive oxygen species production by the Cu(A$\beta $) species: a structure–activity relationship |
| title_sort | reduced schiff base derivatives to stop reactive oxygen species production by the cu a beta species a structure activity relationship |
| topic | Copper Alzheimer Peptide 2N2O ligand Oxidative stress |
| url | https://comptes-rendus.academie-sciences.fr/chimie/articles/10.5802/crchim.255/ |
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