Reduced Schiff-base derivatives to stop reactive oxygen species production by the Cu(A$\beta $) species: a structure–activity relationship

Reduced Schiff-base derivatives to stop reactive oxygen species production by the Cu(A$\beta $) species: a structure–activity relationship

A${\beta }$ is the peptide involved in Alzheimer’s disease. Its binding to the redox copper ions and the subsequent production of reactive oxygen species (ROS) contributing to the overall oxidative stress observed in the disease is among the deleterious effects A${\beta }$ may have. Here seven reduc...

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Bibliographic Details
Main Authors: Lefèvre, Margot, Lantigner, Lielou, Andolfo, Laura, Vanucci-Bacqué, Corinne, Benoist, Eric, Esmieu, Charlène, Bedos-Belval, Florence, Hureau, Christelle
Format: Article
Language:English
Published: Académie des sciences 2023-10-01
Series:Comptes Rendus. Chimie
Subjects:
Copper
Alzheimer
Peptide
2N2O ligand
Oxidative stress
Online Access:https://comptes-rendus.academie-sciences.fr/chimie/articles/10.5802/crchim.255/
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https://comptes-rendus.academie-sciences.fr/chimie/articles/10.5802/crchim.255/

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