Ultra-low extracorporeal volume microfluidic leukapheresis is safe and effective in a rat model

Ultra-low extracorporeal volume microfluidic leukapheresis is safe and effective in a rat model

Abstract Leukapheresis is a potentially life-saving therapy for children with symptomatic hyperleukocytosis. However, the standard centrifugation-based approach exposes pediatric patients to significant complications due to its large extracorporeal volume, high flow rates, and considerable platelet...

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Main Authors: Mubasher Iqbal, Alexandra L. McLennan, Anton Mukhamedshin, Mai T. P. Dinh, Qisheng Liu, Jacob J. Junco, Arvind Mohan, Poyyapakkam R. Srivaths, Karen R. Rabin, Thomas P. Fogarty, Sean C. Gifford, Sergey S. Shevkoplyas, Fong W. Lam
Format: Article
Language:English
Published: Nature Portfolio 2025-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-57003-5
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https://doi.org/10.1038/s41467-025-57003-5

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