Altered behaviour and immune response in mice with NHLRC2 p.Asp148Tyr variant

Altered behaviour and immune response in mice with NHLRC2 p.Asp148Tyr variant

Fibrosis, neurodegeneration and cerebral angiomatosis (FINCA) is a childhood-onset neurodevelopmental disorder with multi-organ manifestations, including recurrent infections. It is caused by variants in NHLRC2, initiating a cascade of unknown pathological events.We investigated the FINCA disease-ca...

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Main Authors: Anniina E. Hiltunen, Salla M. Kangas, Aishwarya Gondane, Henna Koivisto, Kari Salokas, Anne Heikkinen, Miia H. Salo, Tapio Röning, Antti Tallgren, Virpi Glumoff, Maria C. Denis, Niki Karagianni, Johanna Myllyharju, Markku Varjosalo, Heikki Tanila, Harri M. Itkonen, Mika Rämet, Johanna Uusimaa, Reetta Hinttala
Format: Article
Language:English
Published: Elsevier 2025-07-01
Series:Brain, Behavior, & Immunity - Health
Subjects:
FINCA disease
NHLRC2
NHL repeat containing 2
Neurodevelopmental disorder
Immune response
Mouse model
Online Access:http://www.sciencedirect.com/science/article/pii/S266635462500078X
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