DPP4-inhibition reduces pro-inflammatory cytokine production by alpha-beta and gamma-delta T cells in vitro and in the biliary atresia mouse model

DPP4-inhibition reduces pro-inflammatory cytokine production by alpha-beta and gamma-delta T cells in vitro and in the biliary atresia mouse model

Abstract Etiology and pathogenesis of biliary atresia (BA) remain elusive. Evidence points to a T cell mediated autoimmune response contributing to the disease by driving the ongoing hepatic inflammation. CD26, also known as dipeptidylpeptidase 4 (DPP4), is an immunoregulatory protein also expressed...

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Bibliographic Details
Main Authors: Anne-Christin Wilde, Marie Uecker, Faikah Gueler, Immo Prinz, Omid Madadi-Sanjani, Claus Petersen, Joachim F. Kuebler, Christian Klemann
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Scientific Reports
Subjects:
Biliary atresia
DPP4
CD26
T cells
IL-17
IFN-γ
Online Access:https://doi.org/10.1038/s41598-025-16097-z
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https://doi.org/10.1038/s41598-025-16097-z

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