Physiologically-based pharmacokinetic modeling of enantioselective hydroxychloroquine kinetics and impact of genetic polymorphisms

Physiologically-based pharmacokinetic modeling of enantioselective hydroxychloroquine kinetics and impact of genetic polymorphisms

Abstract Hydroxychloroquine (HCQ) is a chiral drug used to treat malaria and inflammatory diseases, available as a racemic mixture of R-and S-HCQ. This work aimed to build physiologically-based pharmacokinetic (PBPK) models to predict the pharmacokinetics (PK) of R-and S-HCQ and assess the impact of...

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Bibliographic Details
Main Authors: Gabriella de Souza Gomes Ribeiro, Leandro Francisco Pippa, Fernanda de Lima Moreira, Natália Valadares de Moraes
Format: Article
Language:English
Published: Universidade de São Paulo 2025-01-01
Series:Brazilian Journal of Pharmaceutical Sciences
Subjects:
Hydroxychloroquine
Enantiomers
PBPK
Gene polymorphisms
Drug interactions
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502025000100325&lng=en&tlng=en
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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502025000100325&lng=en&tlng=en

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