Astragaloside IV alleviated bone loss in mice with ovariectomy-induced osteoporosis via modulating gut microbiota and fecal metabolism

Astragaloside IV alleviated bone loss in mice with ovariectomy-induced osteoporosis via modulating gut microbiota and fecal metabolism

BackgroundAstragaloside IV (AS-IV) is one of the most potent components of Astragalus. It has been reported to promote bone formation and inhibit osteoclastogenesis, suggesting its potential as a candidate for the prevention and treatment of postmenopausal osteoporosis (PMOP). The gut microbiota may...

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Bibliographic Details
Main Authors: Huichao Wang, Zhongyue Huang, Guangnan Chen, Yang Li, Youwen Liu, Huijie Gu, Yujing Cao
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Pharmacology
Subjects:
astragaloside IV
osteoporosis
gut microbiota
metabolism
intestinal barrier
oxidative stress
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1548491/full
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https://www.frontiersin.org/articles/10.3389/fphar.2025.1548491/full

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