Threshold-effect of ferritin levels with pathoglycemia in Chinese adults: a cross-sectional study based on China health and nutrition survey data
Abstract Background The present study aimed to explore the threshold-effect association of serum ferritin levels with type 2 diabetes mellitus (T2DM) and prediabetes mellitus in Chinese adults. Methods A total of 8365 people from CHNS a cross-sectional survey in 2009 were finally included. The bioma...
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BMC
2025-01-01
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| Series: | BMC Endocrine Disorders |
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| Online Access: | https://doi.org/10.1186/s12902-024-01822-y |
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| author | Chenyu Yang Jintao Li Chao Li Jinyu Yang Yanpei Gao Guohua Li Xintian Liu Xiaoqin Luo |
| author_facet | Chenyu Yang Jintao Li Chao Li Jinyu Yang Yanpei Gao Guohua Li Xintian Liu Xiaoqin Luo |
| author_sort | Chenyu Yang |
| collection | DOAJ |
| description | Abstract Background The present study aimed to explore the threshold-effect association of serum ferritin levels with type 2 diabetes mellitus (T2DM) and prediabetes mellitus in Chinese adults. Methods A total of 8365 people from CHNS a cross-sectional survey in 2009 were finally included. The biomarker data, including major cardiovascular biomarkers and important nutrition biomarkers were collected. The association of serum ferritin levels with T2DM and prediabetes mellitus were assessed by using restricted cubic spline function combined with multivariate logistic regression model. Results The mean age of the study subjects was 50.3 years, and 46.5% were men. The risk of T2DM and prediabetes mellitus increased when the ferritin level was greater than 140 ng/ml. The OR(OR = 0.59, 95% CI, 0.35–0.98)was lowest between 40 to < 60 ng/ml in men with prediabetes mellitus. The OR(OR = 0.61, 95% CI, 0.41–0.90)was lowest between 20 to < 40 ng/ml in women with prediabetes mellitus. Serum ferritin levels and OR value of women younger than 50 years old are lower than those of other participants. Conclusions There is a correlation between ferritin levels and pathoglycemia, with women under 50 years old having a lower risk for the same ferritin level, and maintaining low levels of ferritin can reduce the risk of developing diabetes mellitus. |
| format | Article |
| id | doaj-art-9a7afe7ad3504824b6675f16f09712af |
| institution | Kabale University |
| issn | 1472-6823 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Endocrine Disorders |
| spelling | doaj-art-9a7afe7ad3504824b6675f16f09712af2025-01-12T12:27:10ZengBMCBMC Endocrine Disorders1472-68232025-01-012511710.1186/s12902-024-01822-yThreshold-effect of ferritin levels with pathoglycemia in Chinese adults: a cross-sectional study based on China health and nutrition survey dataChenyu Yang0Jintao Li1Chao Li2Jinyu Yang3Yanpei Gao4Guohua Li5Xintian Liu6Xiaoqin Luo7School of Public Health and Emergency Management, Southern University of Science and TechnologyDepartment of Nutrition and Food Safety, School of Public Health, Xi’an Jiaotong UniversityDepartment of Epidemiology and Biostatistics, School of Public Health, Xi’an Jiaotong UniversityDepartment of Epidemiology and Biostatistics, School of Public Health, Xi’an Jiaotong UniversityDepartment of Epidemiology and Biostatistics, School of Public Health, Xi’an Jiaotong UniversityDepartment of Nutrition and Food Safety, School of Public Health, Xi’an Jiaotong UniversityDepartment of Nutrition and Food Safety, School of Public Health, Xi’an Jiaotong UniversityDepartment of Nutrition and Food Safety, School of Public Health, Xi’an Jiaotong UniversityAbstract Background The present study aimed to explore the threshold-effect association of serum ferritin levels with type 2 diabetes mellitus (T2DM) and prediabetes mellitus in Chinese adults. Methods A total of 8365 people from CHNS a cross-sectional survey in 2009 were finally included. The biomarker data, including major cardiovascular biomarkers and important nutrition biomarkers were collected. The association of serum ferritin levels with T2DM and prediabetes mellitus were assessed by using restricted cubic spline function combined with multivariate logistic regression model. Results The mean age of the study subjects was 50.3 years, and 46.5% were men. The risk of T2DM and prediabetes mellitus increased when the ferritin level was greater than 140 ng/ml. The OR(OR = 0.59, 95% CI, 0.35–0.98)was lowest between 40 to < 60 ng/ml in men with prediabetes mellitus. The OR(OR = 0.61, 95% CI, 0.41–0.90)was lowest between 20 to < 40 ng/ml in women with prediabetes mellitus. Serum ferritin levels and OR value of women younger than 50 years old are lower than those of other participants. Conclusions There is a correlation between ferritin levels and pathoglycemia, with women under 50 years old having a lower risk for the same ferritin level, and maintaining low levels of ferritin can reduce the risk of developing diabetes mellitus.https://doi.org/10.1186/s12902-024-01822-yThreshold-effectFerritinPathoglycemiaType 2 diabetes mellitus |
| spellingShingle | Chenyu Yang Jintao Li Chao Li Jinyu Yang Yanpei Gao Guohua Li Xintian Liu Xiaoqin Luo Threshold-effect of ferritin levels with pathoglycemia in Chinese adults: a cross-sectional study based on China health and nutrition survey data BMC Endocrine Disorders Threshold-effect Ferritin Pathoglycemia Type 2 diabetes mellitus |
| title | Threshold-effect of ferritin levels with pathoglycemia in Chinese adults: a cross-sectional study based on China health and nutrition survey data |
| title_full | Threshold-effect of ferritin levels with pathoglycemia in Chinese adults: a cross-sectional study based on China health and nutrition survey data |
| title_fullStr | Threshold-effect of ferritin levels with pathoglycemia in Chinese adults: a cross-sectional study based on China health and nutrition survey data |
| title_full_unstemmed | Threshold-effect of ferritin levels with pathoglycemia in Chinese adults: a cross-sectional study based on China health and nutrition survey data |
| title_short | Threshold-effect of ferritin levels with pathoglycemia in Chinese adults: a cross-sectional study based on China health and nutrition survey data |
| title_sort | threshold effect of ferritin levels with pathoglycemia in chinese adults a cross sectional study based on china health and nutrition survey data |
| topic | Threshold-effect Ferritin Pathoglycemia Type 2 diabetes mellitus |
| url | https://doi.org/10.1186/s12902-024-01822-y |
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