Interferon-stimulated circHOMER1 attenuates antiviral innate immunity

Interferon-stimulated circHOMER1 attenuates antiviral innate immunity

ABSTRACT In an initial screening of virus-induced differentially expressed circRNAs, circHOMER1 was significantly upregulated. However, its role in antiviral innate immunity remained unclear. circHOMER1 was upregulated in response to a range of stimuli, including RNA viruses, DNA viruses, as well as...

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Main Authors: Ao Zhang, Ranran Yao, Shijin Geng, Haiying Wang, Rong-Chun Tang, Hengxiang Yu, Rui Xu, Hong-Yan Chen, Yunxuan Zhou, Lan Zhang, Jun Zhang
Format: Article
Language:English
Published: American Society for Microbiology 2025-08-01
Series:mBio
Subjects:
circHOMER1
ceRNA
miR-145-3p
innate immunity
RIG-I
Online Access:https://journals.asm.org/doi/10.1128/mbio.01497-25
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https://journals.asm.org/doi/10.1128/mbio.01497-25

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