Enhancement of plasma kallikrein specificity of antitrypsin variants identified by phage display and partial reversion

Enhancement of plasma kallikrein specificity of antitrypsin variants identified by phage display and partial reversion

Abstract Background The naturally occurring variant Alpha-1 Antitrypsin M358R (AAT M358R), modified at the P1 position of the reactive center loop (RCL), shifts its inhibitory protease target from neutrophil elastase to multiple coagulation and contact proteases, including activated plasma kallikrei...

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Bibliographic Details
Main Authors: Sangavi Sivananthan, Tyler Seto, Negin C. Tehrani, Varsha Bhakta, William P. Sheffield
Format: Article
Language:English
Published: BMC 2025-03-01
Series:BMC Biotechnology
Subjects:
Phage display
Alpha-1 antitrypsin
Plasma kallikrein
Mutagenesis
Reactive centre loop
Hereditary angioedema
Online Access:https://doi.org/10.1186/s12896-025-00956-8
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https://doi.org/10.1186/s12896-025-00956-8

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