Limited utility of ITPA deficiency to predict early anemia in HCV patients with advanced fibrosis receiving Telaprevir.

Limited utility of ITPA deficiency to predict early anemia in HCV patients with advanced fibrosis receiving Telaprevir.

<h4>Background</h4>Severe anemia is a common side effect of Pegylated Interferon + Ribavirin (PR) and Telaprevir (TVR) in hepatitis C virus (HCV) genotype 1 patients with advanced fibrosis or cirrhosis (F3-F4). Inosine triphosphatase (ITPA) genetic variants are associated with RBV- induc...

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Main Authors: Alessio Aghemo, Eleonora Grassi, Maria Grazia Rumi, Roberta D'Ambrosio, Enrico Galmozzi, Elisabetta Degasperi, Davide Castaldi, Roberta Soffredini, Massimo Colombo
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0095881&type=printable
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https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0095881&type=printable

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