Screening of electrospun PS/PCL scaffolds for three-dimensional triple negative breast cancer cell culture: impact of solvent, hydrophobicity, and setup orientation

Screening of electrospun PS/PCL scaffolds for three-dimensional triple negative breast cancer cell culture: impact of solvent, hydrophobicity, and setup orientation

Abstract Triple-Negative Breast Cancer (TNBC) presents a significant challenge due to its aggressiveness and lack of targeted therapies. Understanding the interaction between TNBC cells and the extracellular matrix (ECM) in three-dimensional (3D) culture systems is vital for developing accurate in v...

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Bibliographic Details
Main Authors: Sira Ausellé-Bosch, Marta Pardo, Marta Pareja, Emma Polonio-Alcalá, Teresa Puig
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Electrospinning
Polystyrene
Poly-ε-caprolactone
Scaffolds
Three-dimensional cell culture
Fiber morphology
Online Access:https://doi.org/10.1038/s41598-025-05871-8
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https://doi.org/10.1038/s41598-025-05871-8

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