A1AT dysregulation of metabolically stressed hepatocytes by Kupffer cells drives MASH and fibrosis

A1AT dysregulation of metabolically stressed hepatocytes by Kupffer cells drives MASH and fibrosis

Abstract Metabolic dysfunction-associated steatohepatitis (MASH) is associated with the activation of Kupffer cells (KCs) and hepatic stellate cells, at which point a metabolically stressed hepatocyte becomes integral to the progression of the disease. We observed a significant reduction in the leve...

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Main Authors: Jeong-Su Park, Jin Lee, Feng Wang, Hwan Ma, Zixiong Zhou, Yong-Sun Lee, Kwangyeon Oh, Haram Lee, Guoyan Sui, Sangkyu Lee, Yoon Mee Yang, Jang-Won Lee, Yong-Ha Ji, Chun-Woong Park, Hwan-Soo Yoo, Bang-Yeon Hwang, Sang-Bae Han, Nan Song, Soohwan Oh, Bumseok Kim, Ekihiro Seki, Jin Tae Hong, Yoon Seok Roh
Format: Article
Language:English
Published: Nature Publishing Group 2025-02-01
Series:Experimental and Molecular Medicine
Online Access:https://doi.org/10.1038/s12276-025-01408-1
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https://doi.org/10.1038/s12276-025-01408-1

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