β-cyclodextrin-based multifunctional carriers for colon-targeted drug delivery: advances in hydrogel systems and mucoadhesive strategies

β-cyclodextrin-based multifunctional carriers for colon-targeted drug delivery: advances in hydrogel systems and mucoadhesive strategies

Abstract Oral drug delivery to the colon remains a formidable challenge due to the harsh conditions of the upper gastrointestinal tract, including variable pH, enzymatic degradation, and limited mucosal permeability. β-Cyclodextrin (β-CD), a cyclic oligosaccharide with a hydrophobic cavity and hydro...

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Bibliographic Details
Main Authors: Mousmee Sharma, Parteek Prasher, Rabab Fatima, Daniela Calina, Javad Sharifi-Rad
Format: Article
Language:English
Published: BMC 2025-08-01
Series:Cancer Nanotechnology
Subjects:
β-cyclodextrin
Colonic drug delivery
Hydrogel
Mucoadhesion
pH-responsive system
Site-specific release
Online Access:https://doi.org/10.1186/s12645-025-00339-w
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https://doi.org/10.1186/s12645-025-00339-w

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