Utilization of artificial circular RNAs as miRNA sponges and anti-PD-1 scFv expression platforms to suppress hepatocellular carcinoma progression

Utilization of artificial circular RNAs as miRNA sponges and anti-PD-1 scFv expression platforms to suppress hepatocellular carcinoma progression

BackgroundHepatocellular carcinoma (HCC) is characterized by a complex interplay of genetic and epigenetic alterations that contribute to its aggressive nature and resistance to conventional therapies. The recent advent of immune checkpoint inhibitors has shown promise in enhancing the immune system...

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Bibliographic Details
Main Authors: Yongping Lai, Fei Wang, Guang Cai, Yingying Li, Jiaxin Weng, Feifan Cai, Leijie Cai, Niangmei Cheng, Bixing Zhao, Yongyi Zeng
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Immunology
Subjects:
hepatocellular carcinoma
circular RNA
miRNA sponge
anti-PD-1
scFv antibody
immunotherapy
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1609165/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1609165/full

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