Regional Brain Aging Disparity Index: Region-Specific Brain Aging State Index for Neurodegenerative Diseases and Chronic Disease Specificity

Regional Brain Aging Disparity Index: Region-Specific Brain Aging State Index for Neurodegenerative Diseases and Chronic Disease Specificity

This study proposes a novel brain-region-level aging assessment paradigm based on Shapley value interpretation, aiming to overcome the interpretability limitations of traditional brain age prediction models. Although deep-learning-based brain age prediction models using neuroimaging data have become...

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Bibliographic Details
Main Authors: Yutong Wu, Shen Sun, Chen Zhang, Xiangge Ma, Xinyu Zhu, Yanxue Li, Lan Lin, Zhenrong Fu
Format: Article
Language:English
Published: MDPI AG 2025-06-01
Series:Bioengineering
Subjects:
model interpretability
SHAP
brain age prediction
deep learning
abnormal brain aging
Online Access:https://www.mdpi.com/2306-5354/12/6/607
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