Engineering Lipid Nanoparticles to Enhance Intracellular Delivery of Transforming Growth Factor-Beta siRNA (siTGF-β1) via Inhalation for Improving Pulmonary Fibrosis Post-Bleomycin Challenge

Engineering Lipid Nanoparticles to Enhance Intracellular Delivery of Transforming Growth Factor-Beta siRNA (siTGF-β1) via Inhalation for Improving Pulmonary Fibrosis Post-Bleomycin Challenge

<b>Background/Objectives:</b> Transforming Growth Factor-beta (<i>TGFβ1</i>) plays a core role in the process of pulmonary fibrosis (PF). The progression of pulmonary fibrosis can be alleviated by siRNA-based inhibiting <i>TGF-β1</i>. However, the limitations of n...

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Bibliographic Details
Main Authors: Xu Deng, Yingjie Yang, Liming Gan, Xinliu Duan, Xiwei Wang, Jingyan Zhang, Aiping Wang, Anan Zhang, Zhizhao Yuan, Daquan Chen, Aiping Zheng
Format: Article
Language:English
Published: MDPI AG 2025-01-01
Series:Pharmaceutics
Subjects:
lipid nanoparticles (LNPs)
siRNA delivery
design of experiments (DOE)
pulmonary fibrosis (PF)
transforming growth factor β1 (<i>TGF-β1</i>)
Online Access:https://www.mdpi.com/1999-4923/17/2/157
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