Role and practical guidelines for the use of radiotherapy in neuroblastoma — a narrative review of literature and clinical trial protocols
Neuroblastoma is the most common extracranial solid tumor in children, requiring multidisciplinary treatment, including radiotherapy, which is primarily applied in the high-risk group to prevent disease progression. The review highlights indications for radiotherapy, its role in multimodal treatment...
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| Format: | Article |
| Language: | English |
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Via Medica
2025-01-01
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| Series: | Reports of Practical Oncology and Radiotherapy |
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| Online Access: | https://journals.viamedica.pl/rpor/article/view/106279 |
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| author | Aleksandra Jadwiga Sztuder Marek Ussowicz Agata Szulc Beranarda Kazanowska Adam Jozef Maciejczyk |
| author_facet | Aleksandra Jadwiga Sztuder Marek Ussowicz Agata Szulc Beranarda Kazanowska Adam Jozef Maciejczyk |
| author_sort | Aleksandra Jadwiga Sztuder |
| collection | DOAJ |
| description | Neuroblastoma is the most common extracranial solid tumor in children, requiring multidisciplinary treatment, including radiotherapy, which is primarily applied in the high-risk group to prevent disease progression. The review highlights indications for radiotherapy, its role in multimodal treatment, and addresses aspects of radiotherapy planning, including target volume definition, prescribed radiation doses, optimal timing for radiotherapy implementation, and potential side effects. Particular attention is drawn to the lack of consensus regarding the necessity of an additional radiation dose for persistent residual disease in the primary tumor and the irradiation of metastatic sites remaining after induction therapy. To conclude, monitoring quality assurance in radiotherapy planning and delivering processes based on unified standards appears to be crucial. |
| format | Article |
| id | doaj-art-99e8e04acde946ef800ef4bad2d74e52 |
| institution | Kabale University |
| issn | 1507-1367 2083-4640 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Via Medica |
| record_format | Article |
| series | Reports of Practical Oncology and Radiotherapy |
| spelling | doaj-art-99e8e04acde946ef800ef4bad2d74e522025-08-21T05:46:02ZengVia MedicaReports of Practical Oncology and Radiotherapy1507-13672083-46402025-01-0130310.5603/rpor.106279Role and practical guidelines for the use of radiotherapy in neuroblastoma — a narrative review of literature and clinical trial protocolsAleksandra Jadwiga Sztuder0Marek Ussowicz1Agata Szulc2Beranarda Kazanowska3Adam Jozef Maciejczyk4Department of Oncology, Wroclaw Medical University, Wroclaw, PolandDepartment of Paediatric Bone Marrow Transplantation, Oncology and Haematology, Wroclaw Medical University, Wroclaw, PolandDepartament of Radiotherapy, Lower Silesian Oncology Center Wrocław, Wroclaw, PolandDepartment of Paediatric Bone Marrow Transplantation, Oncology and Haematology, Wroclaw Medical University, Wroclaw, PolandDepartament of Radiotherapy, Lower Silesian Oncology Center Wrocław, Wroclaw, PolandNeuroblastoma is the most common extracranial solid tumor in children, requiring multidisciplinary treatment, including radiotherapy, which is primarily applied in the high-risk group to prevent disease progression. The review highlights indications for radiotherapy, its role in multimodal treatment, and addresses aspects of radiotherapy planning, including target volume definition, prescribed radiation doses, optimal timing for radiotherapy implementation, and potential side effects. Particular attention is drawn to the lack of consensus regarding the necessity of an additional radiation dose for persistent residual disease in the primary tumor and the irradiation of metastatic sites remaining after induction therapy. To conclude, monitoring quality assurance in radiotherapy planning and delivering processes based on unified standards appears to be crucial.https://journals.viamedica.pl/rpor/article/view/106279radiotherapyneuroblastomatarget volume |
| spellingShingle | Aleksandra Jadwiga Sztuder Marek Ussowicz Agata Szulc Beranarda Kazanowska Adam Jozef Maciejczyk Role and practical guidelines for the use of radiotherapy in neuroblastoma — a narrative review of literature and clinical trial protocols Reports of Practical Oncology and Radiotherapy radiotherapy neuroblastoma target volume |
| title | Role and practical guidelines for the use of radiotherapy in neuroblastoma — a narrative review of literature and clinical trial protocols |
| title_full | Role and practical guidelines for the use of radiotherapy in neuroblastoma — a narrative review of literature and clinical trial protocols |
| title_fullStr | Role and practical guidelines for the use of radiotherapy in neuroblastoma — a narrative review of literature and clinical trial protocols |
| title_full_unstemmed | Role and practical guidelines for the use of radiotherapy in neuroblastoma — a narrative review of literature and clinical trial protocols |
| title_short | Role and practical guidelines for the use of radiotherapy in neuroblastoma — a narrative review of literature and clinical trial protocols |
| title_sort | role and practical guidelines for the use of radiotherapy in neuroblastoma a narrative review of literature and clinical trial protocols |
| topic | radiotherapy neuroblastoma target volume |
| url | https://journals.viamedica.pl/rpor/article/view/106279 |
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