SETD2 drives METTL14-mediated m6A to suppress Piezo1 Attenuation and activate TGM2 to promote pulmonary hypertension

SETD2 drives METTL14-mediated m6A to suppress Piezo1 Attenuation and activate TGM2 to promote pulmonary hypertension

Abstract Background Pulmonary arterial hypertension (PAH) is characterized by pathological vascular remodeling driven by pulmonary artery smooth muscle cell (PASMC) proliferation. While METTL14-mediated N6-methyladenosine (m6A) RNA modification has been implicated in PAH, the upstream regulators and...

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Bibliographic Details
Main Authors: Shuai-shuai Zhao, Chuan Yuan, Jin-long Liu, Qi-cai Wu, Xue-liang Zhou
Format: Article
Language:English
Published: Springer 2025-08-01
Series:Cellular and Molecular Life Sciences
Subjects:
Pulmonary arterial hypertension
Epigenetic modification
SETD2
METTL14
Piezo1
Online Access:https://doi.org/10.1007/s00018-025-05809-3
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https://doi.org/10.1007/s00018-025-05809-3

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