Ebola virus VP35 interacts non-covalently with ubiquitin chains to promote viral replication.

Ebola virus VP35 interacts non-covalently with ubiquitin chains to promote viral replication.

Ebolavirus (EBOV) belongs to a family of highly pathogenic viruses that cause severe hemorrhagic fever in humans. EBOV replication requires the activity of the viral polymerase complex, which includes the cofactor and Interferon antagonist VP35. We previously showed that the covalent ubiquitination...

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Main Authors: Carlos A Rodríguez-Salazar, Sarah van Tol, Olivier Mailhot, Maria Gonzalez-Orozco, Gabriel T Galdino, Abbey N Warren, Natalia Teruel, Padmanava Behera, Kazi Sabrina Afreen, Lihong Zhang, Terry L Juelich, Jennifer K Smith, María Inés Zylber, Alexander N Freiberg, Rafael J Najmanovich, Maria I Giraldo, Ricardo Rajsbaum
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2024-02-01
Series:PLoS Biology
Online Access:https://journals.plos.org/plosbiology/article/file?id=10.1371/journal.pbio.3002544&type=printable
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https://journals.plos.org/plosbiology/article/file?id=10.1371/journal.pbio.3002544&type=printable

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