Discovery of Isobavachin, a Natural Flavonoid, as an Apolipoprotein E4 (ApoE4) Structure Corrector for Alzheimer’s Disease

Discovery of Isobavachin, a Natural Flavonoid, as an Apolipoprotein E4 (ApoE4) Structure Corrector for Alzheimer’s Disease

Alzheimer’s disease (AD) is a progressive neurodegenerative disease characterized by extensive neurodegeneration and consequent severe memory loss. Apolipoprotein E4 (ApoE4) is the strongest genetic risk factor for AD, with its pathological effects linked to structural instability and altered intera...

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Bibliographic Details
Main Authors: Sachin P. Patil, Bella R. Kuehn, Christina McCullough, Dean Bates, Hadil Hazim, Mamadou Diallo, Naomie Francois
Format: Article
Language:English
Published: MDPI AG 2025-02-01
Series:Molecules
Subjects:
Alzheimer’s disease
Apolipoprotein E4 (ApoE4)
flavonoids
Isobavachin
structure correctors
protein stabilization
Online Access:https://www.mdpi.com/1420-3049/30/4/940
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