Successful targeting of multidrug-resistant tumors with bispecific antibodies

Successful targeting of multidrug-resistant tumors with bispecific antibodies

Multidrug resistance (MDR) hinders efficacious cancer chemotherapy. Overexpression of the P-glycoprotein (P-gp) efflux pump (EP) on cancer cells is a primary cause of MDR since it expels numerous anticancer drugs. Small molecule intracellular P-gp antagonists have been investigated clinically to red...

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Bibliographic Details
Main Authors: Raffaella Briante, Qianting Zhai, Suchismita Mohanty, Pingping Zhang, Alissa O’Connor, Hiwot Misker, Willie Wang, Cindy Tan, Mastewal Abuhay, Jessica Morgan, Richard Theolis, Paul Ponath, Robert Arathoon
Format: Article
Language:English
Published: Taylor & Francis Group 2025-12-01
Series:mAbs
Subjects:
multidrug resistance
efflux pumps
P-gp
bispecific antibodies
chemotherapy
small molecule antagonist
Online Access:https://www.tandfonline.com/doi/10.1080/19420862.2025.2492238
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https://www.tandfonline.com/doi/10.1080/19420862.2025.2492238

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