Effectiveness of a booster dose of aerosolized or intramuscular adenovirus type 5 vectored COVID-19 vaccine in adults: a multicenter, partially randomized, platform trial in China

Effectiveness of a booster dose of aerosolized or intramuscular adenovirus type 5 vectored COVID-19 vaccine in adults: a multicenter, partially randomized, platform trial in China

Abstract We conducted a multicenter, partially randomized, platform trial to assess the effectiveness of a booster dose of an aerosolized or intramuscular adenovirus type 5 vectored COVID-19 vaccine (Ad5-nCoV) in Chinese adults (NCT05855408). Between May 23, 2023, and August 28, 2023, 4089 eligible...

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Main Authors: Siyue Jia, Yuanbao Liu, Qian He, Hongxing Pan, Zhenglun Liang, Juan Zhou, Yingzi Pan, Sheng Liu, Jingjing Wu, Kun Yang, Xuanxuan Zhang, Yang Zhao, Simin Li, Lei Zhang, Li Chen, Aihua Yao, Mengyi Lu, Fengcai Zhu, Qunying Mao, Jingxin Li
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-58327-y
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https://doi.org/10.1038/s41467-025-58327-y

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