Structure-based design of potent and selective inhibitors of the HECT ligase NEDD4

Structure-based design of potent and selective inhibitors of the HECT ligase NEDD4

Abstract Among the human E3 ubiquitin ligases, NEDD4 (Neural precursor cell expressed developmentally down-regulated 4) plays a critical role in development and cancer, making it a compelling therapeutic target. However, no specific NEDD4 inhibitors have advanced in drug development. In this study,...

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Main Authors: Elena Maspero, Anna Cappa, Janine Weber, Paolo Trifirò, Raffaella Amici, Agostino Bruno, Giovanni Fagà, Valentina Cecatiello, Raimondo Fattori, Brian Leuzzi, Vincenzo Taibi, Giuseppe Meroni, Maurizio Pasi, Alessia Romussi, Luca Sartori, Manuela Villa, Stefania Vultaggio, Marco Cirò, Paolo Soffientini, Lierin Lombardo, Shakti Dahe, Angela Bachi, Mario Varasi, Mario Rossi, Sebastiano Pasqualato, Ciro Mercurio, Simona Polo
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Communications Chemistry
Online Access:https://doi.org/10.1038/s42004-025-01557-4
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https://doi.org/10.1038/s42004-025-01557-4

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