Population pharmacokinetic analysis of rivaroxaban in healthy volunteers and patients with radiofrequency ablation of non-valvular atrial fibrillation in China

Population pharmacokinetic analysis of rivaroxaban in healthy volunteers and patients with radiofrequency ablation of non-valvular atrial fibrillation in China

AimsThis study aimed to develop a population pharmacokinetic (PopPK) model of rivaroxaban in healthy volunteers and patients with radiofrequency ablation of non-valvular atrial fibrillation (NVAF) in China and investigate the effect of potential covariates on pharmacokinetic (PK) parameters.MethodsP...

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Bibliographic Details
Main Authors: Fangfang Gu, Kaixian Tang, Cong Zhang, Mingsheng Hu, Junlong Sun, Xiang Yu, Mengli Tian, Chen Zhang, Yingrong Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Pharmacology
Subjects:
rivaroxaban
population pharmacokinetics
modeling and simulation
non-valvular atrial fibrillation
Chinese population
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1562259/full
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https://www.frontiersin.org/articles/10.3389/fphar.2025.1562259/full

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