Ultradeep N-glycoproteome atlas of mouse reveals spatiotemporal signatures of brain aging and neurodegenerative diseases

Abstract The current depth of site-specific N-glycoproteomics is insufficient to fully characterize glycosylation events in biological samples. Herein, we achieve an ultradeep and precision analysis of the N-glycoproteome of mouse tissues by integrating multiple workflows. The largest N-glycoproteom...

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Bibliographic Details
Main Authors: Pan Fang, Xiangming Yu, MengYang Ding, Cong Qifei, Hongyu Jiang, Qi Shi, Weiwei Zhao, Weimin Zheng, Yingning Li, Zixiang Ling, Wei-Jun Kong, Pengyuan Yang, Huali Shen
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-60437-6
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