The role of IP3 receptors and SERCA pumps in restoring working memory under amyloid β induced Alzheimer's disease: a modeling study

Memory impairment is a prevalent symptom in patients with Alzheimer's disease (AD), with working memory loss being the most prominent deficit. Recent experimental evidence suggests that abnormal calcium levels in the Endoplasmic Reticulum (ER) may disrupt synaptic transmission, leading to memor...

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Bibliographic Details
Main Authors: Ziyi Huang, Lei Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Computational Neuroscience
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fncom.2025.1643547/full
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