Optimizing formulation and development of amlodipine-indapamide bilayer film-coated tablets with in vitro dissolution equivalence to a reference drug

Optimizing formulation and development of amlodipine-indapamide bilayer film-coated tablets with in vitro dissolution equivalence to a reference drug

This study aimed to develop and optimize a bilayer tablet containing immediate-release amlodipine and sustained-release indapamide for the treatment of hypertension. Using BCPharSoft OPT software, individual layer formulations were optimized: 8.63% croscarmellose sodium for the amlodipine layer and...

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Main Authors: Duyen Thi My Huynh, Tuan Duc Nguyen, Quyen Hoang Nguyen, Tai Nguyen Thanh Dao, An Doan Quynh Nguyen, Nguyen Ngoc Khoi Nguyen, Mai Thi Anh Nguyen, Lan Kim Huynh, Minh-Ngoc Thi Le, Tri Vinh Nguyen, Phuoc Huu Le, Son Thanh Khuu
Format: Article
Language:English
Published: Pensoft Publishers 2025-07-01
Series:Pharmacia
Online Access:https://pharmacia.pensoft.net/article/155983/download/pdf/
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https://pharmacia.pensoft.net/article/155983/download/pdf/

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