Integrin αβ–Targeted Dynamic Contrast–Enhanced Magnetic Resonance Imaging Using a Gadolinium-Loaded Polyethylene Gycol–Dendrimer–Cyclic RGD Conjugate to Evaluate Tumor Angiogenesis and to Assess Early Antiangiogenic Treatment Response in a Mouse Xenograft Tumor Model

Integrin αβ–Targeted Dynamic Contrast–Enhanced Magnetic Resonance Imaging Using a Gadolinium-Loaded Polyethylene Gycol–Dendrimer–Cyclic RGD Conjugate to Evaluate Tumor Angiogenesis and to Assess Early Antiangiogenic Treatment Response in a Mouse Xenograft Tumor Model

The purpose of this study was to validate an integrin α v β 3 –targeted magnetic resonance contrast agent, PEG-G3-(Gd-DTPA) 6 -(cRGD-DTPA) 2 , for its ability to detect tumor angiogenesis and assess early response to antiangiogenic therapy using dynamic contrast–enhanced (DCE) magnetic resonance ima...

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Main Authors: Wei-Tsung Chen, Tiffany Ting Fang Shih, Ran-Chou Chen, Shin-Yang Tu, Hsieh Wen-Yuen, Pang-Chyr Yang
Format: Article
Language:English
Published: SAGE Publishing 2012-07-01
Series:Molecular Imaging
Online Access:https://doi.org/10.2310/7290.2011.00050
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https://doi.org/10.2310/7290.2011.00050

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