Uncovering a novel biosynthetic gene cluster for sordarin through genome mining in the fungus Talaromyces adpressus

Uncovering a novel biosynthetic gene cluster for sordarin through genome mining in the fungus Talaromyces adpressus

Abstract To explore the chemical and biological diversities of diterpenoids from the fungus Talaromyces adpressus, a previously unknown biosynthetic gene cluster (BGC, tdn) for sordarin (a well-known fungal antibiotics) was discovered by leveraging the genome mining method. Heterologous expressions...

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Bibliographic Details
Main Authors: Qianqian Xu, Xiaomeng Ren, Linzhen Hu, Qiaoxin Xu, Xiaodong Zhang, Mengyi Deng, Ying Ye, Yonghui Zhang, Yuanyuan Lu, Yuben Qiao
Format: Article
Language:English
Published: SpringerOpen 2025-04-01
Series:Bioresources and Bioprocessing
Subjects:
Sordarin
Biosynthetic gene cluster
Talaromyces adpressus
New compound
Anti-tumor activities
Online Access:https://doi.org/10.1186/s40643-025-00864-x
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https://doi.org/10.1186/s40643-025-00864-x

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