Modulation of copper-induced neurotoxicity by monoisoamyl 2,3-dimercaptosuccinic acid loaded nanoparticles through inhibition of mitophagy and reduction of oxidative stress in SH-SY5Y cells

Modulation of copper-induced neurotoxicity by monoisoamyl 2,3-dimercaptosuccinic acid loaded nanoparticles through inhibition of mitophagy and reduction of oxidative stress in SH-SY5Y cells

Copper (Cu2 +) dysregulation, often stemming from ATP7B gene mutations, exacerbates neurological disorders like Huntington’s, Alzheimer’s, and Parkinson's diseases. Monoisoamyl 2,3-dimercaptosuccinic acid (MiADMSA) shows promise in mitigating Cu2+ induced neurotoxicity by chelating intracellula...

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Bibliographic Details
Main Authors: Akshada Mhaske, Rahul Shukla, S.J.S. Flora
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Toxicology Reports
Subjects:
MiADMSA
Box-Behnken design
Mitophagy
Apoptosis
Metal chelation
Oxidative stress
Online Access:http://www.sciencedirect.com/science/article/pii/S2214750024002579
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