Cathepsin D promotes acute myeloid leukemia progression through stabilization of the anti-apoptotic proteins

Cathepsin D promotes acute myeloid leukemia progression through stabilization of the anti-apoptotic proteins

Abstract Cathepsin D (CTSD) is a lysosomal aspartic protease that plays vital roles in regulating the properties of solid tumors, including proliferation, apoptosis, migration, metastasis, and angiogenesis. However, the function of CTSD in haematological malignancies remains largely elusive. Here we...

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Main Authors: Huimin Jiang, Yongjian Wang, Churan Wang, Lu Yang, Shujuan Wang, Feng Wang, Situ Xue, Zhuan Zhang, Haigen Fu, Ting Dong, Jian Yuan, Zhuorong Li, Ke Li
Format: Article
Language:English
Published: Nature Publishing Group 2025-08-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-025-07949-7
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https://doi.org/10.1038/s41419-025-07949-7

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