A broadly neutralizing antibody recognizes a unique epitope with a signature motif common across coronaviruses

A broadly neutralizing antibody recognizes a unique epitope with a signature motif common across coronaviruses

Abstract Cross-reactive antibodies targeting multiple epitopes have been identified in Sarbecoviruses, but the precise molecular mechanism(s) behind the crossreactivity remain poorly understood. Here, we isolate 3D1, a broadly neutralizing antibody (bnAb) derived from a human combinatorial antibody...

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Main Authors: Lei Yan, Fulian Wang, Michelle Hill, Juliane Brun, Ze Liang, Xinyu Shi, Liangminghui Zhang, Xiuxiu He, Yu Li, Qianping Huang, Xuxue Dong, Huanzhen Liu, Yi Zhang, Lili Liu, Raymond A. Dwek, Nicole Zitzmann, Aibin Liang, Guang Yang
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-63101-1
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https://doi.org/10.1038/s41467-025-63101-1

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