Unveiling the hidden dance: SPP1 + macrophages identified in ulcerative colitis reveal crosstalk with CHI3L1 + fibroblasts

Unveiling the hidden dance: SPP1 + macrophages identified in ulcerative colitis reveal crosstalk with CHI3L1 + fibroblasts

Abstract Background Ulcerative colitis (UC) is a chronic inflammatory bowel disease characterized by persistent inflammation of the colon. The specific cause of UC is still not fully understood, but this condition is believed to arise from a combination of environmental, genetic, microbial, and immu...

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Main Authors: Peiwen Zhou, Tongyu Tang, Pingwei Zhao, Quan Wang, Xintong Hu, Junzhuo Si, Tianshi Yang, Shuai Zhou, Wenyan An, Yanfang Jiang
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Journal of Translational Medicine
Subjects:
Ulcerative colitis
SPP1 + macrophages
CHI3L1 + fibroblasts
Regulatory networks
scRNA-seq
Online Access:https://doi.org/10.1186/s12967-025-06565-5
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https://doi.org/10.1186/s12967-025-06565-5

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