Gain of 20q11.21 in human pluripotent stem cells enhances differentiation to retinal pigment epithelium

Gain of 20q11.21 in human pluripotent stem cells enhances differentiation to retinal pigment epithelium

Abstract Background Cell therapies based on human pluripotent stem cells (hPSCs) are in clinical trials with the aim of restoring vision in people with age-related macular degeneration. The final cell therapy product consists of retinal pigment epithelium (RPE) cells differentiated from hPSCs. Howev...

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Bibliographic Details
Main Authors: Loriana Vitillo, Fabiha Anjum, Zoe Hewitt, Owen Laing, Nidaa A. Ababneh, Duncan Baker, Ivana Barbaric, Peter J. Coffey
Format: Article
Language:English
Published: BMC 2025-02-01
Series:Stem Cell Research & Therapy
Subjects:
Age-related macular degeneration
Retinal pigment epithelium
Pluripotent stem cells
Copy number variant
BCL-XL
Tumorigenicity
Online Access:https://doi.org/10.1186/s13287-025-04196-7
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https://doi.org/10.1186/s13287-025-04196-7

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