Effect of neurohormonal therapeutic in left ventricle global and regional function in Chagas cardiomyopathy in a translational animal experimental model

Effect of neurohormonal therapeutic in left ventricle global and regional function in Chagas cardiomyopathy in a translational animal experimental model

Abstract Neurohormonal benefits of Chronic Chagas’ Cardiomyopathy (CCC) remain controversial. This study aimed to assess therapeutic interventions on CCC evolution in T. cruzi-infected hamsters at pre and post-treatment (2 months with beta-blocker (CH + BB) or ACE inhibitor (CH + ACEI)). Echocardiog...

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Main Authors: Denise Mayumi Tanaka, Beatriz de Paula Dias Zara, André Timoteo Sapalo, Arthur Lauand Vargas, José Antonio Marin-Neto, Antônio Carlos Leite de Barros-Filho, Cibele M. Prado Zinni, Keila Cardoso Barbosa Fonseca, Maykon Tavares de Oliveira, João Santana Silva, Felix Jose Alvarez Ramires, Maria de Lourdes Higuchi, Marcus Vinicius Simões, Minna Moreira Dias Romano
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Scientific Reports
Subjects:
Chronic Chagas´ cardiomyopathy
Animal experimental model
Speckle tracking echocardiography
Neurohormonal treatment
Myocardial function
Online Access:https://doi.org/10.1038/s41598-025-96676-2
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https://doi.org/10.1038/s41598-025-96676-2

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